Bayern Munich and Atletico Madrid took giant strides toward the Champions League quarterfinals with big wins Tuesday, while Liverpool and Barcelona still have work to do.

Bayern thrashed Atalanta 6-1 without top scorer Harry Kane in the starting lineup. And Atletico made under-pressure Tottenham coach Igor Tudor pay for his bold call to drop first-choice goalkeeper Guglielmo Vicario by racing to a 3-0 lead inside 15 minutes. The Spanish giant eventually won 5-2.

Liverpool needs to overturn a 1-0 defeat to Galatasaray in next week's second leg at Anfield and Barcelona needed Lamine Yamal's penalty with the last kick of the game to rescue a 1-1 draw at Newcastle.

Goals galore

Even without the prolific Kane, Bayern all but sealed its place in the last eight with a dominant win at Atalanta.

In his absence, Michael Olise scored twice, Serge Gnabry and Nicolas Jackson each scored and set up goals, while Josip Stanisic and Jamal Musiala were also on target for the German champion.

Kane's alma mater Tottenham endured a nightmare start in Madrid, with backup keeper Antonin Kinsky substituted in the 17th minute after his mistakes led to two of Atletico's three early goals.

Spurs coach Tudor had opted to leave out first choice Vicario — a decision that backfired spectacularly. Kinsky was making his Champions League debut and his slip and miskick in the sixth minute gave Marcos Llorente the chance to open the scoring.

Antoine Griezmann made it 2-0 for Atletico, before another Kinsky miskick allowed Julian Alvarez to slot the ball into an empty net.

Kinsky looked inconsolable when he was replaced by Vicario, who conceded just five minutes after coming on — Robin Le Normand scoring Atletico's fourth.

"We knew how to take advantage of our opponents' mistakes to gain a good lead, and now we go into the second leg with a three-goal advantage," Alvarez said.

Spurs rallied, but it will take an unlikely comeback in the second leg to avoid elimination.

"We gave away three goals at the start, and then it became very difficult for us," Tudor said.

According stats provider Opta, this was the first time in Tottenham's history that it has lost six games in a row.

Lamine's late show

Five-time European champion Barcelona was seconds away from defeat when Malick Thiaw brought down Dani Olmo in the box.

Eighteen-year-old Yamal had the composure to beat Aaron Ramsdale, despite the home fans baying for him to miss. His goal was timed at 96 minutes and the full-time whistle was blown immediately afterward.

"It wasn't a great game from us, but we have a young team," Barcelona coach Hansi Flick said. "We have to improve, but we have a lot of potential. We have to make things better, and we will."

Newcastle led through Harvey Barnes' close-range effort in the 86th minute. The forward had also hit the post with an earlier curling effort.

"It's tough. You score and it's an amazing feeling — you can feel the fans. We'd played really well," Barnes said. "To concede late on is really hard to take, but the score is level and we have a second leg to come."

Turkish delight

First it was Juventus, and now Liverpool. Galatasaray is cutting a swath through European soccer's giants.

Mario Lemina's seventh-minute header secured the first-leg win for the Turkish champion, which stunned Juventus with a 7-5 aggregate victory in the playoffs.

It is the second time Galatasaray has beaten Liverpool in Istanbul this season, having won by the same scoreline in the league phase.

It had chances to widen the gap, with Victor Osimhen's second-half strike ruled out for offside. Liverpool saw Ibrahima Konate's effort disallowed by VAR for handball.

"We've lost here twice with 1-0,"Liverpool coach Arne Slot said. "The good thing is that the next game is at Anfield and our fans can create a similar atmosphere."