US Marshals on Wednesday seized a $9.4 million luxury home in Florida belonging to disgraced Wall Street financier Bernard Madoff and his wife after earlier confiscating two of their leisure boats.

There was no one living inside at the time as the federal agents moved into the two-story property at 410 North Lake Way, Palm Beach, set amid carefully manicured lawns and hedges on Florida's Intracoastal Waterway.

"We are securing the house, changing all the locks on the house ... we are taking a complete inventory," Barry Golden of the US Marshals Service said.